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Optellum, an Oxford-based lung health company aiming to redefine early diagnosis and treatment of lung disease, has received FDA clearance for its AI-powered clinical decision support software.
Restoring Function to a Variant of p53 in Solid Tumors.
Journal article
Lu X., (2026), N Engl J Med, 394, 922 - 925
Mutational Signatures and Clonal Hematopoiesis in Intestinal Metaplasia across Countries with Varying Stomach Cancer Incidence.
Journal article
Huang KK. et al, (2026), Cancer Discov, OF1 - OF24
Calcium signaling is required for anterior patterning in the mouse embryo.
Journal article
Stower MJ. et al, (2025), PLoS Biol, 23
Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site.
Journal article
Chen S. et al, (2025), Cancer Cell, 43, 1590 - 1592
Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro.
Journal article
Lotz R. et al, (2025), Cell Death Dis, 16
Cardiocutaneous syndrome is caused by aggregation of iASPP mutants.
Journal article
Lotz R. et al, (2024), Cell Death Discov, 10
Microscale droplet assembly enables biocompatible multifunctional modular iontronics.
Journal article
Zhang Y. et al, (2024), Science, 386, 1024 - 1030
Absolute quantitative and base-resolution sequencing reveals comprehensive landscape of pseudouridine across the human transcriptome.
Journal article
Xu H. et al, (2024), Nat Methods, 21, 2024 - 2033
Prospective cohort for early detection of liver cancer (Pearl): a study protocol.
Journal article
Khanna K. et al, (2024), BMJ Open, 14
Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironment.
Journal article
Ma J. et al, (2024), Proc Natl Acad Sci U S A, 121
A T-cell signature in circulating cell-free DNA at time of diagnosis predicts response to checkpoint inhibition
Poster
Xie P. et al, (2024), CLINICAL CANCER RESEARCH, 30
A T-cell signature in circulating cell-free DNA at time of diagnosis predicts response to checkpoint inhibition
Poster
Xie P. et al, (2024), CLINICAL CANCER RESEARCH, 30
High tumor monocyte content predicts long-term survival for patients with operable oesophageal cancer treated with neoadjuvant immunochemotherapy in the LUD2015-005 trial
Poster
Fuchs HS. et al, (2024), CANCER RESEARCH, 84
Tolerance of Whole Genome Duplication in Megakaryocytes, and Consequences for Their Genome Integrity
Poster
Rodriguez-Romera A. et al, (2024), BLOOD, 144, 421 - 422
A cell-free DNA methylation biomarker outperforms irRECIST in predicting treatment outcome
Poster
Xie P. et al, (2024), CANCER RESEARCH, 84
Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases.
Journal article
Pagnamenta AT. et al, (2023), Genome Med, 15
ASPP2 binds to hepatitis C virus NS5A protein via an SH3 domain/PxxP motif-mediated interaction and potentiates infection.
Journal article
Smirnov A. et al, (2023), J Gen Virol, 104
Mutational order and epistasis determine the consequences of FBXW7 mutations during colorectal cancer evolution
Preprint
Chan DKH. et al, (2023)
Tumor monocyte content predicts immunochemotherapy outcomes in esophageal adenocarcinoma.
Journal article
Carroll TM. et al, (2023), Cancer Cell, 41, 1222 - 1241.e7
p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer.
Journal article
Miller P. et al, (2023), Cell Death Differ, 30, 1619 - 1635