Françoise Howe
Scientific Coordinator
Support role
My responsibilities are split between the Oxford Centre for Early Cancer Detection and the Ludwig Institute for Cancer Research, Oxford branch.
Within the Oxford Centre for Early Cancer Detection (OxCODE), I coordinate early detection research across Oxford, manage communications and provide scientific grant writing support.
Within Ludwig Oxford, I oversee the management of research data. My other Ludwig roles include LICR Oxford branch communications, including maintenance of the website, and organising public engagement activities.
Background
I did my PhD and post-doc with Prof. Jane Mellor in the Department of Biochemistry, Oxford. My research focused on the role of chromatin and antisense transcription in the regulation of gene transcription, using yeast as a model organism.
Key publications
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Antisense transcription-dependent chromatin signature modulates sense transcript dynamics.
Journal article
Brown T. et al, (2018), Mol Syst Biol, 14
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CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape.
Journal article
Howe FS. et al, (2017), Elife, 6
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Is H3K4me3 instructive for transcription activation?
Journal article
Howe FS. et al, (2017), Bioessays, 39, 1 - 12
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Lysine acetylation controls local protein conformation by influencing proline isomerization.
Journal article
Howe FS. et al, (2014), Mol Cell, 55, 733 - 744
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Transcription mediated insulation and interference direct gene cluster expression switches.
Journal article
Nguyen T. et al, (2014), Elife, 3