Françoise Howe
OxCODE Scientific Coordinator
PROFessional Services role
I coordinate the Oxford Centre for Cancer Early Detection and Prevention (OxCODE). This involves managing key early detection and prevention research projects across Oxford, promoting our success through communications and providing scientific grant writing support.
Background
I did my PhD and post-doc with Prof. Jane Mellor in the Department of Biochemistry, Oxford. My research focused on the role of chromatin and antisense transcription in the regulation of gene transcription, using yeast as a model organism.
Key publications
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Antisense transcription-dependent chromatin signature modulates sense transcript dynamics.
Journal article
Brown T. et al, (2018), Mol Syst Biol, 14
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CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape.
Journal article
Howe FS. et al, (2017), Elife, 6
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Is H3K4me3 instructive for transcription activation?
Journal article
Howe FS. et al, (2017), Bioessays, 39, 1 - 12
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Lysine acetylation controls local protein conformation by influencing proline isomerization.
Journal article
Howe FS. et al, (2014), Mol Cell, 55, 733 - 744
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Transcription mediated insulation and interference direct gene cluster expression switches.
Journal article
Nguyen T. et al, (2014), Elife, 3