PROFessional Services role
I coordinate the Oxford Centre for Early Cancer Detection (OxCODE). This involves managing key early detection research projects across Oxford, promoting our success through communications and providing scientific grant writing support.
I did my PhD and post-doc with Prof. Jane Mellor in the Department of Biochemistry, Oxford. My research focused on the role of chromatin and antisense transcription in the regulation of gene transcription, using yeast as a model organism.
Antisense transcription-dependent chromatin signature modulates sense transcript dynamics.
Brown T. et al, (2018), Mol Syst Biol, 14
CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape.
Howe FS. et al, (2017), Elife, 6
Is H3K4me3 instructive for transcription activation?
Howe FS. et al, (2017), Bioessays, 39, 1 - 12
Lysine acetylation controls local protein conformation by influencing proline isomerization.
Howe FS. et al, (2014), Mol Cell, 55, 733 - 744
Transcription mediated insulation and interference direct gene cluster expression switches.
Nguyen T. et al, (2014), Elife, 3